Publications
A collection of my research work. (^: Equally Contributed, *: Corresponding Authors)
Conference Papers
Distilled Prompt Learning for Incomplete Multimodal Survival Prediction
Yingxue Xu, Fengtao Zhou, Chenyu Zhao, Yihui Wang, Can Yang, Hao Chen*
CVPR, 2025
Prototypical Information Bottlenecking and Disentangling for Multimodal Cancer Survival Prediction
Yilan Zhang^, Yingxue Xu^, Jianqi Chen, Fengying Xie, Hao Chen*
ICLR, 2024 (Spotlight, top-5%)
HistGen: Histopathology Report Generation via Local-Global Feature Encoding and Cross-modal Context Interaction
Zhengrui Guo, Jiabo Ma, Yingxue Xu, Yihui Wang, Liansheng Wang, Hao Chen*
MICCAI, 2024
Journal Papers
Towards generalizable AI in medicine via Generalist–Specialist Collaboration
Sunan He, Yuxiang Nie, Hongmei Wang, Shu Yang, Yihui Wang, Zhiyuan Cai, Zhixuan Chen, Yingxue Xu, Luyang Luo, Huajun Xiang, Xi Lin, Mingxiang Wu, Yifan Peng, George Shih, Ziyang Xu, Xian Wu, Qiong Wang, Ronald Cheong Kin Chan, Varut Vardhanabhuti, Winnie Chiu Wing Chu, Yefeng Zheng, Pranav Rajpurkar, Kang Zhang, Hao Chen*
Nature Biomedical Engineering, 2026
A Multimodal Knowledge-enhanced Whole-slide Pathology Foundation Model
Yingxue Xu^, Yihui Wang^, Fengtao Zhou^, Jiabo Ma, Cheng Jin, Shu Yang, Jinbang Li, Zhengyu Zhang, Chenglong Zhao, Huajun Zhou, Zhenhui Li, Huangjing Lin, Xin Wang, Jiguang Wang, Anjia Han, Ronald Cheong Kin Chan, Li Liang, Xiuming Zhang, Hao Chen*
Nature Communications, 2025
Interpretable and robust multimodal data integration for precise treatment response and survival prediction in gastric cancer
Fengtao Zhou, Yingxue Xu, Yanfen Cui, Shenyan Zhang, Yun Zhu, Weiyang He, Dafu Zhang, Jiguang Wang, Xin Wang, Ronald Cheong Kin Chan, Louis Ho Shing Lau, Chu Han, Zhenhui Li*, Hao Chen*
The Innovation Informatics, 2025
A Generalizable Pathology Foundation Model using A Unified Knowledge Distillation Pretraining Framework
Jiabo Ma, Zhengrui Guo, Fengtao Zhou, Yihui Wang, Yingxue Xu, Jinbang Li, Fang Yan, Yu Cai, Zhengjie Zhu, Cheng Jin, Yi Lin, Xinrui Jiang, Chenglong Zhao, Danyi Li, Anjia Han, Zhenhui Li, Ronald Cheong Kin Chan, Jiguang Wang, Peng Fei, Kwang-Ting Cheng, Shaoting Zhang*, Li Liang*, Hao Chen*
Nature Biomedical Engineering, 2025
Histo-Genomic Knowledge Association For Cancer Prognosis From Histopathology Whole Slide Images
Zhikang Wang, Yumeng Zhang, Yingxue Xu, Seiya Imoto, Hao Chen, Jiangning Song
IEEE Transactions on Medical Imaging, 2025
Modeling Hierarchical Structural Distance for Unsupervised Domain Adaptation
Yingxue Xu, Guihua Wen, Yang Hu, Pei Yang*
IEEE Transactions on Circuits and Systems for Video Technology, 2024
Task-Coupling Elastic Learning for Physical Sign-based Medical Image Classification
Yingxue Xu, Guihua Wen*, Pei Yang, Baochao Fan, Yang Hu, Mingnan Luo, Changjun Wang
IEEE Journal of Biomedical and Health Informatics, 2021 (Perspective Featured Article)
Multiple Attentional Pyramid Networks for Chinese Herbal Recognition
Yingxue Xu, Guihua Wen, Yang Hu, Mingnan Luo, Dan Dai, Yishan Zhuang, Wendy Hall
Pattern Recognition, 2020
Preprints
A Breast Vision Pathology Foundation Model for Real-world Clinical Utility
Yingxue Xu^, Zhengyu Zhang^, Xiuming Zhang^, Mengwei Xu, Fengtao Zhou, Yihui Wang, Jiabo Ma, Yi Xin, Danyi Li, Chengyu Lu, Zhijian Cen, Ying Tan, Qingbing Yao, Qi Wang, Zizhao Gao, Yong Zhang, Jingjing Chen, Feifei Liu, Qian Xu, Yi Dai, Hongxuan Tan, Cheng Jin, Huajun Zhou, Zhengrui Guo, Ling Liang, Hongyi Wang, Yingcong Chen, Xi Wang, Zhenhui Li*, Ronald Cheong Kin Chan*, Ning Mao*, Muyan Cai*, Zhe Wang*, Li Liang*, Hao Chen*
2026
Spatial Transcriptomics-Guided Alignment Enhances Molecular Profiling in Pathology Foundation Model
Fengtao Zhou, Yingxue Xu, Zhengyu Zhang, Yihui Wang, Zhengrui Guo, Ling Liang, Jiabo Ma, Cheng Jin, Ziyi Liu, Huajun Zhou, Hongyi Wang, Du Cai, Chenglong Zhao, Xi Wang, Can Yang, Yu Wang, Wenbin Li, Feng Gao, Zhe Wang, Zhenhui Li, Xiuming Zhang, Li Liang, Hao Chen*
2026
A Clinically Validated Foundation Model for Comprehensive Lung Pathology Interpretation
Zhengrui Guo, Zhengyu Zhang, Jiabo Ma, Yihui Wang, Fengtao Zhou, Yingxue Xu, Ling Liang, Chenglong Zhao, Qi Xie, Jinbang Li, Shujing Guo, Fangyi Han, Zhijian Cen, Ziyi Liu, Cheng Jin, Junlin Hou, Zhixuan Chen, Yu Cai, Lijuan Qu, Shifu Chen, Yueping Liu, Zhe Wang, Xiuming Zhang, Muyan Cai*, Li Liang*, Hao Chen*
2026
A Deployment-Friendly Foundational Framework for Efficient Computational Pathology
Yu Cai, Cheng Jin, Jiabo Ma, Fengtao Zhou, Yingxue Xu, Zhengrui Guo, Yihui Wang, Zhengyu Zhang, Ling Liang, Yonghao Tan, Pingcheng Dong, Du Cai, On Ki Tang, Chenglong Zhao, Xi Wang, Can Yang, Yali Xu, Jing Cui, Zhenhui Li, Ronald Cheong Kin Chan, Yueping Liu, Feng Gao, Xiuming Zhang, Li Liang, Hao Chen*, Kwang-Ting Cheng
2026
PathBench: A comprehensive comparison benchmark for pathology foundation models towards precision oncology
Jiabo Ma^, Yingxue Xu^, Fengtao Zhou^, Yihui Wang, Cheng Jin, Zhengrui Guo, Jianfeng Wu, On Ki Tang, Huajun Zhou, Xi Wang, Luyang Luo, Zhengyu Zhang, Du Cai, Zizhao Gao, Wei Wang, Yueping Liu, Jiankun He, Jing Cui, Zhenhui Li, Jing Zhang, Feng Gao, Xiuming Zhang, Li Liang, Ronald Cheong Kin Chan, Zhe Wang, Hao Chen*
2025
MambaMIL+: Modeling Long-Term Contextual Patterns for Gigapixel Whole Slide Image
Qian Zeng, Yihui Wang, Shu Yang, Yingxue Xu, Fengtao Zhou, Jiabo Ma, Dejia Cai, Zhengyu Zhang, Lijuan Qu, Yu Wang, Li Liang, Hao Chen*
2025
LLM-driven Knowledge Enhancement for Multimodal Cancer Survival Prediction
Chenyu Zhao^, Yingxue Xu^, Fengtao Zhou, Yihui Wang, Hao Chen*
2025
GenAR: Next-Scale Autoregressive Generation for Spatial Gene Expression Prediction
Jiarui Ouyang, Yihui Wang, Yihang Gao, Yingxue Xu, Shu Yang, Hao Chen*
2025
A Multimodal Foundation Model to Enhance Generalizability and Data Efficiency for Pan-cancer Prognosis Prediction
Huajun Zhou, Fengtao Zhou, Jiabo Ma, Yingxue Xu, Xi Wang, Xiuming Zhang, Li Liang, Zhenhui Li, Hao Chen*
2025
A Versatile Pathology Co-pilot via Reasoning Enhanced Multimodal Large Language Model
Zhe Xu, Ziyi Liu, Junlin Hou, Jiabo Ma, Cheng Jin, Yihui Wang, Zhixuan Chen, Zhengyu Zhang, Fuxiang Huang, Zhengrui Guo, Fengtao Zhou, Yingxue Xu, Xi Wang, Ronald Cheong Kin Chan, Li Liang, Hao Chen*
2025
Genomic Touchstone: Benchmarking Genomic Language Models in the Context of the Central Dogma
Yihui Wang, Zhiyuan Cai, Qian Zeng, Yihang Gao, Jiarui Ouyang, Yingxue Xu, Shu Yang, Sunan He, Yuxiang Nie, Yu Cai, Fengtao Zhou, Cheng Jin, Xi Wang, Zhi Xie, Danqing Zhu, Ting Xie, Kwang-Ting Cheng, Can Yang, Xi Fu, Jiguang Wang, Kang Zhang, Jianhua Yao, Raul Rabadan, Hao Chen*
2025
Genome-Anchored Foundation Model Embeddings Improve Molecular Prediction from Histology Images
Cheng Jin, Fengtao Zhou, Yunfang Yu, Jiabo Ma, Yihui Wang, Yingxue Xu, Huajun Zhou, Hao Jiang, Luyang Luo, Luhui Mao, Zifan He, Xiuming Zhang, Jing Zhang, Ronald Chan, Herui Yao, Hao Chen*
2025
Multimodal data integration for precision oncology: Challenges and future directions
Huajun Zhou, Fengtao Zhou, Chenyu Zhao, Yingxue Xu, Luyang Luo, Hao Chen*
2024